[Info-area3] PhD Day Doctorate GenOMeC 2018 - 26 settembre 2018

[FRULLANTI ELISA]

PhD Day 2018
Doctorate in Genetics, Oncology and Clinical Medicine (GenOMeC)
September 26, 2018

Room 2 of the Polo Didattico Le Scotte , University of Siena
Viale Bracci,2– Siena


9.00 	Welcome Addresses
Francesco Frati, Rector of the University of Siena

Opening
9.30 Alessandra Renieri (UniSI), Director of the Doctorate in Genetics, 
Oncology and Clinical Medicine


9.45-10.15  HAEMATONCOLOGY
Chairmen:  MonicaBocchia  (UniSI), Patrizia Tunici(AOUS)

9.45 Ferrigno Ilaria, 1styearcourse (Tutor: M. Bocchia, UniSI)
Prognosticrole of isocitratedehydrogenase 1 and 2 (IDH1/IDH2) mutations 
in Acute MyeloidLeukemia

10.00 Brogi Alice, 2nd year course (Tutor: V. Santini, UniFI)
Mechanisms of resistance to hypomethylating agents in MDS/AML syndromes.


10.15-12.00 MELANOMA AND SKIN / EYE DISEASE
Chairmen: Persio Della Sbarba (UniFi), Pietro Rubegni (UniSI)

10.15 Anichini Giulia ,1st yearcourse (Tutor: B. Stecca, ISPRO)
Exploring the role of the sialyltransferase ST3GAL1 in melanoma

10.30 Cannito Sara, 1st year course (Tutor: M. Maio  AOUS)
Modeling of cancer immune phenotype by new epigenetic drugs: a strategy 
to improve efficacy ofimmunotherapy

10.45 D’Angelo Costantino,1styearcourse (Tutor: A. GiordanoUniSI)
Evaluation of anti-proliferative and antioxidant potential of tomatoes 
extracts against melanoma

11.00 Fulco Begnamino, 1st year course (Tutor: A. Giordano, UniSI)
Preventive and antiproliferative effects of tomato extracts on 
colorectal cancer

11.15 Monterisi Sara, 1st year course (Tutor: M. Maio, AOUS)
Immune-remodeling activity of epigenetic drugs as bases for novel 
combinatorial immunotherapy clinical trials for cancer patients

11.30 Tognetti Linda, 2nd  year course (Tutor: P. Rubegni, UniSI)
Clinical and laboratory characterization of patients with localized 
scleroderma and response to UVA-1 phototherapy: in vivo and in vitro 
skin models.

11.45 Cesari Daniele, 2nd yearcourse (Tutor: A. Giordano, UniSI)
PRMT5 as two-in-one strategy for mesothelioma treatment.

12.00– 12.45 RHEUMATOLOGIC AND HEART DISEASES
Chairmen: AntonellaFioravanti (UniSI), Pier Leopoldo Capecchi(UniSI)

12.00 Beltrami Matteo, 1st year course (Tutor: R. NutiUniSI),
Multimodality imaging in cardiomyopathies: correlation with genetic and 
pathological substrates, functional capacity, prognostic stratification 
and virtual modeling.

12.15 Materozzi Maria, 2nd year course (Tutor: R. Nuti, UniSi)
Molecular biology of Paget’s Disease of Bone: role of p62 and novel 
genes.

12.30 Finizola Francesco, 2nd year course (Tutor: F. LaghiPasini, UniSi)
Systemic inflammation and atrial electrical remodelling: the role of 
IL6-mediated changes in connexins expression.

12.45 – 13.30 LUNG DISEASE AND TUMOR
Chairmen: Elena Bargagli(UniSI),Elisa Frullanti (UniSi)

12.45 Bergantini Laura ,1st year course (Tutor: P Rottoli, UniSI)
Analysis of Biomarkers in Interstitial Lung Disease (ILD)

13.00 Fui  Annalisa, 1st yearcourse(Tutor: P Rottoli, UniSI)
Rituximab Therapy in Interstitial Lung Disease (ILD) associated with 
Rheumatoid Artrhitis (RA)

13.15 Palmieri Maria, 1st year course (Tutor: E. Frullanti ,UniSi)
Whole exome sequencing approach in sib pairs identified oligogenic 
germline mutations predisposing to early lung adenocarcinoma in 
non-smokers

13.30 – 14.00 LUNCH

14.00– 15.30 MOLECULAR ONCOLOGY
Chairmen: Maria De Angioletti (ISPRO), Mario Chiariello (ISPRO)

14.00 Cosi Irene, 2nd year course (Tutor: M. De Angioletti, ISPRO)
Transcriptional regulation and oncogenic effects of the genes 
deregulated by the prostate-specific expression of ETV4.

14.15 Leonardi Margherita, 2nd year course (Tutor: M. Chiariello, ISPRO)
Activated Kinases screening identifies the IKBKEoncogene as a positive 
regulator of autophagy

14.30 Laera letizia, 2nd  year course (Tutor: G. Francini, UniSi – A. Di 
Leo, Usl4-Prato)
Exploratory investigation of serum metabolomics as predictive biomarkers 
of response to checkpoint inhibitors in patients with advanced 
non-small-cell lung cancer (NSCLC).

14.45 Altieri Angela, 2ndyear course (Tutor: A. Giordano, UniSi)
Development of new technologies for identification of a novel proteins 
involved in the DNA damage response (DDR).

15.00 Dell’Aquila Milena, 1st year course(Tutor: A. Giordano, UniSI)
Phosphoproteomic screening reveals the multiple functions of cdk9 in DNA 
damage response

15.15 Dapporto Francesca, 1st yearcourse(Tutor: M. Chiariello, ISPRO)
Role of MAPK15 protein in human tumors

15.30- 17.30 DNA AND RNA EDITING
Chairmen: Silvo Conticello (ISPRO),Francesa Mari (Unisi)

15.30 Croci Susanna, 1st year course (Tutor: S. Giannotti, UniSi)
FOXG1 gene therapy using CRISPR/Cas9 technology and AAVs system.

15.45 Lorenzetti Flaminia Clelia, 1st year course (Tutor: F. Mari, 
UniSi)
Targeting patient-specific TP53 mutations in drug-resistant Chronic 
Lymphocytic Leukemia (CLL) by CRISPR-Cpf1

16.00 Lembo Gaia, 1st year course (Tutor: S. Conticello, ISPRO)
Engineering RNA editing adenosine deaminases to act on DNA

16.15 Tarantino Danilo, 1st year course (Tutor: S. Conticello, ISPRO)
The weight of APOBEC mutations in cancer development

16.30 Donati Francesco, 2nd year course (Tutor: S. Conticello, ISPRO)
APOBEC1 mutants to assess RNA and DNA editing component in cancer.

16.45 Martignano Filippo, 1st year course (Tutor: S. Conticello, ISPRO)
APOBECs, mobile elements and cancer: a bioinformatic approach.

17.00 Chieca Martina, 2nd year course (Tutor: S. Conticello, ISPRO)
Dimerization of APOBEC1 is dispensable for RNA editing.

17.15 Di Giorgio Salvatore, 2nd yearcourse (Tutor: S. Conticello, ISPRO)
APOBEC1-dependent RNA editing, a bioinformatics approach.

17.30 – 19.00 MEDICAL GENETICS
Chairmen: Francesca Ariani (UniSI),Lucia Migliore (UniPI)

17.30 Catania Lorenza Maria, 2nd year course (Tutor: A. Renieri, UniSi)
Disturbance of GABA-ergic transmission in FOXG1 neurons.

17.45 Gelli Elisa, 2nd year course (Tutor: F. Ariani, UniSi)
Splicing impact of BRCA1/2 unclassified variants.

18.00 Paganini Irene, 2nd year course (Tutor: L. Papi)
Identification of novel schwannomatosis genes through exome sequencing

18.15 Nicolì Vanessa, 1st year course (Tutor: L. Migliore)
Environmental factors of prenatal risk: a study on epigenetic 
modifications in human placentas and buccal mucosa cells of newborns.

18.30 Gallo Roberta, 1st year course (Tutor: L. Migliore)
Methylation analysis in girls with Autism Spectrum Disorders (ASD)

18.45 Farhad Jahanfar, 1st year course (Tutor: A. Argangeli)
High-throughput screening of analgesic compounds

19.00  Closing session and meeting of the faculty board

19.15 Attribution of credits by the faculty board



-- 
Dr. Frullanti Elisa, PhD
Medical Genetics
University of Siena, Policlinico S Maria alle Scotte
Viale Bracci, 2 - 53100 - Siena - Italy
Phone: +39 0577 233303
FAX: +39 0577 233325